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Large-Scale Trial Of HIV Vaccine Launched In South Africa
Washington (AFP) Feb 08, 2007 South Africa has launched Africa's largest-yet clinical trial of a promising vaccine against HIV, the virus which causes AIDS, the US National Institutes of Health announced Thursday. About 3,000 men and women who do not have HIV will be enrolled in the program to test the vaccine, supplied by drugmaker Merck and Co., which in earlier, smaller trials proved effective in more than half the people who received it. "Our best hope of ending the AIDS epidemic is a safe and effective vaccine," said NIH director Elias Zerhouni in a statement. "To achieve that goal requires the concerted effort of governments, scientists and private industry as well as participation by well-informed volunteers." The trial is being undertaken by the South African AIDS Vaccine Initiative (SAAVI) and the HIV Vaccine Trials Network (HVTN), together with NIH's National Institute of Allergy and Infectious Diseases. The NIH said the trial is in the phase II "test of concept" phase for the vaccine, designed to generate preliminary information on the efficacy of the vaccine before deciding on a larger phase III trial which, if successful, could lead to licensing and mass production of the vaccine. The trial will involve volunteer men and women between 18 and 35, with some receiving the test vaccine and others a placebo, to determine whether the vaccine can prevent HIV from infecting someone or if it can suppress the level of HIV early on in those who do become infected. NIH said that the vaccine contains copies of only three key HIV genes, and not the entire HIV virus, so that those receiving it will not be infected with HIV. The vaccine has already been tested on some 1,800 people, and since two years ago a separate trial has been ongoing in the United States, Canada, South America, the Caribbean and Australia.
Source: Agence France-Presse Community Email This Article Comment On This Article Related Links US National Institutes of Health The science and news of Epidemics on Earth Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola
AIDS Vaccine Closer But Remains Elusive
Washington (UPI) Feb 08, 2007The launch of the first large-scale AIDS vaccine trial could bring the world one step closer to the elusive goal of preventing the disease's spread, researchers say, but there is still a long road to a marketable vaccine. The trial is "part of a complex and multi-faceted strategy," said Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, which is partially funding the research. |
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