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Harmless Virus May Help Fight Bird Flu
West Lafayette, Ind (UPI) Sep 14, 2005 Purdue University researchers say a harmless virus used as a delivery vehicle for vaccines might help prevent a pandemic of bird flu. Purdue molecular virologist Suresh Mittal and colleagues are investigating a new way to provide immunity against avian influenza viruses, or bird flu. The most lethal strain, H5N1, has a 50-percent fatality rate in humans. Under a $1.6 million grant from the National Institute of Allergy and Infectious Diseases, the Purdue researchers are focusing on using adenovirus as a transmitting agent for a vaccine to fight such highly virulent strains of avian influenza. A major advantage to using adenovirus is that it can be mass produced much more quickly than with current methods. "The ultimate goal of our research is to develop an effective avian influenza virus vaccine that will provide long-lasting and broad immunity against multiple strains of this virus," Mittal said.
Less virulent bird flu may infect humans Crossing the species barrier is an important step in the development of a flu virus with pandemic potential, the scientists noted. Previous studies have focused on the ability of highly pathogenic bird flu strains, such as H5N1 in Asia, spreading to humans. The new study, however, shows less pathogenic strains are also capable of jumping to humans. Isabella Donatelli of Istituto Superiore di Sanita in Rome and colleagues studied outbreaks in northern Italy occurring among poultry between 1999 and 2003. The investigators said their work provides the first serologic evidence of transmission of low pathogenic strains of avian influenza virus to humans during an outbreak in domestic poultry. The researchers emphasize their study probably underestimates the real infection rate because blood samples were considered positive only if they repeatedly produced unequivocal positive results using several different serologic techniques. Details of the study appear in the Oct. 1 issue of The Journal of Infectious Diseases, now available online. Community Email This Article Comment On This Article Related Links SpaceDaily Search SpaceDaily Subscribe To SpaceDaily Express Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola
Less Threatening Bird Flu
Washington (UPI) Jan 11, 2006Talk about good news and bad news: While more cases of avian flu are identified in both birds and humans in Turkey, the first possible signs emerged that the virus itself might not be as lethal as feared. |
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